Praxair’s ControLyo™ technology is a critical, quality driven, cost-saving tool that is becoming the cornerstone of pharmaceutical freeze drying applications. It is a novel and scalable method for controlling nucleation during the freezing step in commercial lyophilization. By introducing a carefully timed depressurization event during the freezing cycle, nucleation will occur simultaneously in all vials. Relying on pressure control, the ControLyo technology is highly adaptable and can be retrofitted to most freeze dryers with minimal impact on established lyophilization protocols. And ControLyo technology does not require any changes to existing drug formulations.