To Filter Or Not To Filter In HPLC? Now, That's A Question.

High-Performance Liquid Chromatography (HPLC) can be both high pressure in workflow and results. Accurate analyses depend on various steps and processes working just so. An analytical lab might deal with hundreds of samples per week, each requiring fast analysis generating reliable results. This means the analyst needs to find and maintain the optimum balance between pace and quality.

Filtration can play a key role (or not) in the HPLC workflow (Fig 1). It can be essential to delivering a clean mobile phase to the column, or it can create its own challenges. Either way, there’s no getting away from it. Not quite, anyway.