12.08.21 -- Maximizing mRNA, Gene Therapy For CAD, Cornering The Antibody Market And More

Check out the latest episodes from Cell & Gene: The Podcast and Business of Biotech. As a member of the Life Science Connect community, you have access to content beyond our weekly newsletters including our podcast series. Don’t forget to subscribe so you never miss an episode!

Carisma Therapeutics’ Dr. Debora Barton breaks down the latest in CAR-M technology as well as the company's Phase 1 first-in-human study of adenovirally transduced anti-HER2 CAR macrophages in subjects with HER2 overexpressing solid tumors.

XyloCor Therapeutics' EXACT clinical trial is a Phase 1/2 multicenter, open-label, single-arm, dose escalation trial for coronary artery disease — the most common type of heart disease — with gene therapy at its center.

Dr. Amy Nicole Nayar, VP of U.S. Patient Advocacy and Government Affairs at Novartis Gene Therapies, explains what patient engagement should encompass in the cell and gene field as well as the unique challenges cell and gene therapy companies face where a patient engagement officer provides essential help.

Ten-year-old Akesobio's stats are mindboggling: Twenty drug development programs, 12 antibodies in clinical-stage development, six bispecific antibodies (two at clinical stage), four antibodies with IND approvals, and 22 clinical trials initiated. CEO Michelle Xia, Ph.D., shares how the company has managed such supercharged growth.

Homology Medicines' approaches to gene therapy and gene editing have the potential to disrupt both the gene therapy space and the mAb manufacturing and administration paradigms. Here, Homology president and CEO Arthur Tzianabos, Ph.D., shares the company's approach and rationale for investing in its own development and manufacturing capacity.

Dr. James Taylor, president and CEO at Precision Nanosystems, believes genomic medicine will ultimately become the largest therapeutic class. Listen in as Dr. Taylor discusses why RNA and DNA delivery are game-changers, and what Precision Nanosystems is doing to push the ball downfield.  

Sarepta Therapeutics’ director of pharmaceutical engineering, Brian Winstead, and Project Farma VP Tony Khoury discuss what flexible manufacturing means, where it works, and where it doesn't. Listen in as Winstead shares the flexible manufacturing philosophy in place at Sarepta.