News | January 22, 2014

Hamilton Robotics Partners With Coastal Genomics To Introduce Innovative Technologies To Automate Agarose Gel DNA Fragment Selection

Source: Hamilton Company

Enables agarose gel size selection in just two hours

At the annual Society for Laboratory Automation and Screening (SLAS) meeting Hamilton Robotics has announced a partnership with Coastal Genomics to launch the new Microlab NIMBUS Select workstation with Ranger Technology. The new automated workstationprovides a faster and more economical automated solution to agarose gel selection of DNA fragments, generating high-quality material for downstream use in next-generation sequencing (NGS), cloning and gene synthesis applications.

The partnership with Coastal Genomics has enabled Hamilton Robotics to access an innovative technology, validated at one of the world’s largest genome centers, and expands the applications available on the NIMBUS workstation. Ranger TechnologytargetsDNA and isolates fractions with high sensitivity and accuracy;recovery yields typically exceed 80% of the intrinsic content in the targeted range.

“The workstation offers high quality, gel-based size selection at a scale that meets the demands of any lab," explained Matthew Nesbitt, President of Coastal Genomics. "However, it also generates analytics that can be used to assess the input sample both before and after the size selection event. This feature could consolidate multiple processes into a single run with Ranger Technology.”

Agarose gel size selection is a key component in sample preparation and quality control used throughout the life sciences. By automating pipetting steps, the NIMBUS Select Workstation with Ranger Technology eliminates manual gel preparation,which is considered one of the most labor-intensive and error-prone steps. In an average two-hour run, the workstationcan accurately process up to 96 samples and then place the fragments in destination labware.

Coastal Genomics’ technology has been successfully validated to size select thousands of DNA samples processed bya major scientific research center in British Columbia.The centerhas effectively eliminated manual agarose gel size selection for multiple sequencing protocols for sample types involving microRNA, genomic DNA and formalin-fixed paraffin-embedded (FFPE) tissue.

The NIMBUS Select Workstation with Ranger Technologyoffersnumerous performance and quality control benefits over manual processing and other automated platforms. As an open automation platform,the workstation can be used for many applications and works with multiple NGS instrumentmanufacturers. The NIMBUS instrument's 96-channel CO-RE head provides an unmatched pipetting dynamic range of 1μL to 1,000μL..

Because sample processing does not always come in precise 96-sample batches, the workstation has thebuilt-in flexibility to automate workflows from one to 96 samples at a time. Quality control metrics,including individual gel images and electropherogram traces,are captured foreach sample.

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About Hamilton Company
Hamilton Company is a global leader in the design and manufacture of liquid handling, process measurement, robotics and storage solutions, serving customers in academic and private research laboratories, pharmaceutical and clinical diagnostic companies and government institutions. Hamilton maintains headquarters in Reno, Nevada; Franklin, Massachusetts; and Bonaduz, Switzerland, along with subsidiary offices throughout the world. For over 60 years, the company has maintained its commitment to building precision and quality into every product. Hamilton is a privately held company with ISO 9001 certification. For more information visit,

About Costal Genomics
Coastal Genomics Inc. develops and markets automated solutions for the sample preparation needs of the Life Sciences community. We have partnered with Hamilton Robotics to port the Ranger Technology for automated size selection to the Microlab NIMBUS automated workstation. The instrument can recover target DNA while generating complementary qualitycontrol analytics for up to 96 samples in a run. RangerTechnology will be well receivedby groups that are looking to collapse size selection andanalysis workflows into a single automated run.

SOURCE: Hamilton Company