Today, there are two main methods of isolation. You can isolate an entire room – i.e. sealing it off from the environment outside. This is usually known as a “cleanroom” solution.
As an alternative, a barrier can be placed just around the process. Two types of barrier are common in the industry today: A Barrier Isolator or a Restricted Access Barrier System (or RABS).
The essence of a Barrier Isolator is that it may be completely sealed, and may therefore be controlled and bio-decontaminated (usually using a chemical sterilant such as Hydrogen Peroxide Vapor). A complete production process may be contained within a series of isolators, thus separating the main contaminants (i.e. the surrounding facility and operators) from the process. The benefit of isolation technology is outlined on the following pages, but it is clear from the illustrations below.