High-performance liquid chromatography (HPLC) systems are widely used in analytical laboratories. Ensuring that systems are in good working order minimizes equipment downtime and increases lab efficiency.
Problems in an HPLC system can arise from several sources. The source of a given problem can often be identified by looking at the system itself or by checking downstream, by looking at the chromatogram.
Recognizing visible signs of in-system issues can identify potential problems and determine solutions that extend the usable lifetime of a column. Maximizing column lifetime has benefits in data quality, cost, and in reducing downtime.