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Title |
Abstract | Posted |
Size |
|---|---|---|---|
| Article: Verification Methods For 198 Common Raw Materials Using A Handheld Raman Spectrometer | Pharmaceutical manufacturers are seeking ways to maintain and improve product quality while reducing manufacturing costs, including in the analytical testing of raw materials. Movement toward 100% inspection of raw materials as well as increased production volumes and the desire for lean manufacturing are additional motivations to find more cost-effective testing technologies. By Robert L. Green, Robert Brush, Wayne Jalenak, and Christopher D. Brown | 09/01/2010 | 443.7 KB |
| Article: Leaning QC: Lonza Rolls Out Raman For Materials ID | As part of an effort to Lean its raw material QC process, Lonza Biologics’ Portsmouth, New Hampshire facility evaluated several new spectroscopic technologies—Raman, NIR, and FTIR handheld or portable devices—for rapidly verifying incoming raw materials. By paul thomas, senior editor | 09/01/2010 | 209.7 KB |
| Article: Chemical Identity Testing By Remote-Based Dispersive Raman Spectroscopy | This paper discusses the use of hand-held Raman spectrometers for the development of qualitative chemical identification methods for a number of well-known pharmaceutical products (tablets and capsules). Methods were developed on two different instruments and transferred to a third instrument for application of the methodology to independently obtained drug products. By DAVID E. BUGAY and ROBERT C. BRUSH | 09/01/2010 | 723.9 KB |
| Application Note: Satisfying GMP With Handheld Near-Infrared Analyzers In The Pharmaceutical Industry | Pharmaceutical manufacturing is a highly regulated industry as manufacturers of excipients, actives and finished forms need to conform to GMP. For example, in the European Union, EudraLex provides guidance for GMP practices and European Pharmocopeia (Ph. Eur.) recommends instrumentation and analysis protocols. By Thermo Fisher Scientific (formerly Ahura Scientific and Polychromix) | 09/01/2010 | 279.3 KB |
| Application Note: Transferring Spectral Libraries From Reference Instruments To The PHAZIR | Transfer of spectra used for calibrations is frequently used when large collections of spectra are difficult to reproduce. The effort to reproduce the calibration set is prohibitive or the samples that comprise the calibration set are ephemeral. By F. G. Haibach | 09/01/2010 | 280.2 KB |
| White Paper: What Does Your Plant Spend On Raw Material Identity Verification? The Answer May Surprise You | Drug manufacturers must verify the identity of their incoming raw materials prior to release into the production process. For some, meeting this requirement involves extracting and testing samples from a small fraction of their incoming containers; for others it means testing every single package. By Thermo Fisher Scientific (formerly Ahura Scientific and Polychromix) | 09/01/2010 | 3.58 MB |
| White Paper: Handheld Raman Instruments For Pharmaceutical Raw Material Inspection: From The Lab To The Loading Dock | The purpose of this paper is to discuss the application of Raman spectroscopy to the unique requirements of raw material testing. By Thermo Fisher Scientific (formerly Ahura Scientific and Polychromix) | 08/31/2010 | 1.81 MB |
| Tech Note: Thermo Scientific TruScan Fast, Cost-Effective Method Development | Thermo Scientific TruScan is a rugged, handheld system for rapid material verification. On-the-spot results are delivered in seconds with nondestructive point-andshoot sampling through sealed packaging. TruScan® reduces the need for quarantine areas and staging of raw materials, while minimizing risk of exposure and contamination. By Thermo Fisher Scientific (formerly Ahura Scientific and Polychromix) | 08/31/2010 | 312.1 KB |
| Miele PROFile Magazine | Miele’s commercial product division, Professional, serves a diverse array of industries. From dental and laboratory to commercial laundry providers, estate homes and shipboard installations, there’s literally no boundary Miele can not cross. | 08/31/2010 | 3.87 MB |
| Application Note: Using A Laboratory Glassware Washer To Perform Pasteurization | Pasteurization is a thermal treatment applied to foods to destroy pathogens. In the food and beverage industry, tunnel washers are often used to pasteurize bottles of beverages in a production line. Within R & D flavors laboratories, new flavors and additives are tested for heat stability prior to being used in new formulations and production. Typically, pasteurization here is performed with a bench top pasteurization system, in a stove-top immersion bath. By Miele Professional | 08/30/2010 | 618.0 KB |
| White Paper: Understanding Powder Caking | Caking, or unwanted agglomeration, presents major problems in powder processing, capable of making even those powders that are normally free-flowing and easily processable, challenging. Its control depends on understanding the influence of, and closely managing, environmental conditions. By Tim Freeman, Freeman Technology | 08/24/2010 | 109.2 KB |
| Summer 2010 Freeman Technology Newsletter: Ten Years On | Freeman Technology this year celebrates ten years in powder testing and it has certainly been a pivotal time for understanding these challenging materials. | 08/24/2010 | 212.1 KB |
| White Paper: Analytical Techniques For Successful Cosmetic Compact Manufacture | Many cosmetics are produced as compacts that, when packaged, are convenient to use and aesthetically pleasing to the consumer. Formulated to give the desired performance in terms of finished effect and ease of application, these discs of compressed powder are typically blends of emollients, preservatives, pigments, fillers and binders. By Tim Freeman, Freeman Technology | 08/24/2010 | 132.7 KB |
| White Paper: Choosing The Best Construction Material For Powder Processing Equipment | Selecting the best material of construction is a crucial part of the plant design process, the aim being to balance performance and cost to best advantage. By Tim Freeman, Freeman Technology | 08/24/2010 | 335.4 KB |
| Application Note: Chiral HPLC Separation Of Enatiomers Of Racemic Drugs Used In Pharmaceutical Industry | A large percentage of commercial and investigational pharmaceutical compounds are enantiomers, and many of them show significant enantioselective differences in their pharmacokinetics and pharmacodynamics. By Orochem Technologies Inc. | 08/09/2010 | 153.4 KB |
| Application Note: Determination Of LC-MS Extractables In 1cc SPE Columns | Solid-phase extraction (SPE) is an extraction method that uses a solid phase (Silica based sorbent packed in polypropylene columns) and a liquid phase (mostly organic) to isolate various type of analyte (s) from a solution. By Chetna Mittal and Asha Oroskar, Orochem Technologies Inc. | 08/09/2010 | 98.4 KB |
| Application Note: HPLC Analysis For The Monitoring Of Fermentation Broth During ABE Fermentation Using Orofuel Fermentation Monitoring Column | With the growing impetus on bio-based renewable and environmentally friendly fuels, we have observed an exponential growth in the ethanol industry. The industry is moving towards next generation biofuels such as butanol and isobutanol. By Dr. Chetna Mittal and Dr. Asha Oroskar, Orochem Technologies Inc. | 08/09/2010 | 43.8 KB |
| Application Note: Total Drug Analysis Of Biological Samples Using An Automated High Throughout Protein Crash Methodology | A mixture of Alkylphenones was analyzed in Serum by Automated Protein Crash Methodology using the Orochem Protein Crash Filter Device and OroFlex Autosampler using High Performance Liquid Chromatography. By Asha Oroskar & Chetna Mittal, Orochem Technologies Inc. | 08/08/2010 | 49.8 KB |
| Article: Collaboration Enables Faster Time To Market | Whether generic or branded, in the high-stakes race to bring a therapeutic drug to market, manufacturers are engaged in two simultaneous challenges. By Herman Mitchell | 08/05/2010 | 50.8 KB |
| Article: Assessing Patient Recruitment Location To Improve Trial Performance | Innovation, cost-effective processes, and emerging markets are probably three of the most common topics being discussed in the pharmaceutical and biopharmaceutical markets today. By Dan Schell | 08/05/2010 | 56.5 KB |
| Datasheet: Nitrogen Generator NM32LA | Our new Genius range of Gas Generators is smoother,quieter, safer and more efficient than anything on the market. The Genius range offers superb technical performance in the lab and comes with our ‘world-class’ after sales service as standard. | 08/04/2010 | 571.2 KB |
| Application Note: Validation Of USEPA Method 524.2 Using A Stratum PTC And The New AQUATek 100 Autosampler | Automation is the key to increasing laboratory productivity and minimizing costs. It is equally important to prove that the changes in technology to achieve these results may be done without sacrificing sample integrity or data quality. The AQUATek 100 is a new vial autosampler which features many new benefits to help increase productivity, minimize carryover, and provide more flexibility to the end user in terms of maintaining sample integrity and servicing the unit. By Teledyne Tekmar | 08/04/2010 | 600.5 KB |
| Application Note: Analysis Of Geosmin And 2-Methylisoborneol Utilizing The Stratum PTC And Aquatek 70 | Geosmin and 2-Methylisoborneol are organic compounds that have a distinct scent. These compounds also have an extremely low odor detection threshold and because of this, many drinking water laboratories require detection levels of below 10ppt. This application note investigates the detection of Geosmin and 2-Methylisoborneol at a one part per trillion (ppt) level utilizing Purge and Trap (P&T) coupled with a Gas Chromatograph and Mass Spectrometer (GC/MS). By Teledyne Tekmar | 08/04/2010 | 97.9 KB |
| Application Note: Gasoline Range Organics (GRO) By Headspace/GC/FID | Recent oil spills in the Gulf of Mexico and the Great Barrier Reef have renewed interest in the rapid analysis of crude oil byproducts in aqueous and solid samples including sand and commercial fishing products. One of the crude oil constituents, gasoline range organics (GRO) is currently determined by either EPA Method 8015C or Wisconsin’s modified GRO. By Teledyne Tekmar | 08/04/2010 | 116.4 KB |
| White Paper: Controlling Airflow In Class II Biosafety Cabinets | Class II biosafety cabinets are defined by the National Sanitation Foundation (NSF International). By Jim Hunter, Senior Project Engineer, Mark Meinders, Product Manager, and Brian Garrett, Product Specialist, Labconco Corporation | 07/30/2010 | 175.0 KB |