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Raman Spectroscopy: An Evolving Technique – Webinar By Dr. David Bugay Q&A

Ahura Scientific

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Q: What percentage of pharmaceutical related materials are Raman active?
A: From my experience, I have found that approximately >90% of pharmaceutical materials, including APIs, API intermediates, API impurities, and excipients are Raman active. In some cases, fluorescence may be generated during the Raman experiment but typically this background signal does not prevent the use of the Raman features for the particular analytical task.

Q: Can Raman be used to distinguish Ethanol from Alcohol 3A?
A: I have not obtained a Raman spectrum on Alcohol 3A so I can only speculate on the answer for this question. Keeping this in mind, I do imagine that Raman can differentiate between Ethanol (200 proof) and Alcohol 3A. The reason behind this is that Alcohol 3A contains a denaturant (typically at 5% level), and as such, Raman would detect Alcohol 3A as a mixture whereas Ethanol (200 proof) would display a pure spectrum of ethanol.

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