Lyophilization Contract R&D, Consultancy & Troubleshooting

Our Services:

Product Characterisation
In-depth characterisation of your product in terms of its key thermal temperatures and behaviour is the first step in product and process development. This information will provide the foundation for all further R&D, scale-up and QC.

Formulation Development
Formulation Development combines in-depth product characterization with our extensive knowledge of excipients. A well-designed formulation will provide protection from the stresses of freeze drying, whilst also ensuring a thermal profile that is favourable for freeze drying.

Cycle Development
A successful freeze drying cycle will provide reliable, safe processing in a timely and efficient manner. BTL’s cycle development services will tailor the freeze drying process to the requirements of your product and the capabilities of your equipment.

Process Optimisation and Scale-Up
Apparently minor changes in formulation, container or equipment can affect the efficiency and efficacy of a freeze drying cycle. This service will ensure your processes are optimised for your requirements.

Freeze Drying Production
We offer small-scale processing runs to provide process testing, production flexibility, or fall-back capabilities.

Troubleshooting
LyoHealth Check is a complete freeze drying analysis / validation service, utilising an integrated suite of analytical methods to identify and quantify the key freeze drying parameters that are vital for successful process design and optimisation. BTL can then provide advice or assistance with formulation and process to rectify any problem areas. LyoHealth Check can also be used to provide data for regulatory and validation requirements.

Collaborative Research
BTL has significant experience in collaboration with academia and industry and is always keen to explore new relationships which will progress the field of lyophilisation.

Training
BTL provides a range of options in training in freeze drying technology.