It is desirable to minimize endotoxins in purified protein preparations prior to their use in cell-based assays. Vivapure centrifugal anion exchange membrane devices can remove endotoxin from research grade monoclonal antibody solutions simply with high protein recovery.
Endotoxins are lipopolysaccharides (LPS) shed from the outer membrane of gram-negative bacteria. They are released when the bacterial cell dies. Endotoxins interact with cells causing a wide range of detrimental effects.
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